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Dose: 0.25mg daily for weeks 1-2, increased to 0.5mg daily for weeks 3-6 Administration: Subcutaneous injection, rotating between deltoid area and upper chest near the shoulder Duration: 6 weeks total Supporting therapy: Light stretching daily, avoided overhead movements until week 4 Three months out from finishing the protocol, my shoulder still feels solid

Dihydrofolate reductase is a key enzyme in folate metabolism in vivo, responsible for the reduction of dihydrofolate to tetrahydrofolate, which is involved in the methyl shuttle required for the ab initio synthesis of thymidylate and certain amino acids