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Mice were decapitated, their brains were collected and immediately submerged in ice-cold, carbogen-saturated (95% O 2 and 5% CO 2 ) artificial cerebrospinal fluid (aCSF

Indeed, because of the complexity associated with the assessment of cellular redox balance, the term oxidative stress defies a simple pro-oxidant versus antioxidant definition and that the description of an oxidant stress is only useful if the molecular details of the imbalance are known (33, 199)

Unlike apoptosis, necrosis is a caspase-independent pathway that results in plasma membrane rupture and inflammation, while ferroptosis is an iron-dependent form of cell death characterized by overwhelming lipid peroxidation [68]

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