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Description
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon

Studies show that idiopathic autism is characterized by reduced TrkB signaling through the PI3K/Akt/mTOR pathway [119] and via the Eps8/Rac pathway [120]

Most of what we know to date comes from a mix of preclinical research and the biological mechanisms each therapy targets

Journal of Neuroscience Methods, 128, 159172
