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Despite their importance, the high-resolution structure of PMEL amyloids has remained unresolved

We tested PLC2 with a c-terminal deletion of both the proximal CTD and distal CTD (PLC2-818) and a mutation (PLC2-P819A) predicted to disrupt formation of the helix loop helix conformation of the proximal CTD that is stabilized upon G q binding (Figure 7A)

126 Regarding the latter, overlying epidermal hyperplasia and a storiform arrangement of spindle cells amidst sclerotic stroma typical of a benign fibrohistiocytic neoplasm are characteristic

Littlejohn NK et al (2020) A feedback loop governs the relationship between lipid metabolism and longevity