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Consequently, with the lack of gastric intrinsic factor, IFmediated active absorption in the ileum is compromised
[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Amelio PD, Panico A, Spertino E, Isaia GC

They are most effective when used as part of a medical weight loss program that also includes healthy eating, regular exercise, and ongoing clinical supervision

In addition, a 2017 systematic review showed that many medications have highly variable dropout rates
