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Description
Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)
ONeill LA, Kishton RJ, Rathmell J
doi: 10.1002/ibd.22878, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 101
This means that they both cannot be made within the body and must be consumed in the diet
