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Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects

The role of PDI in SARS-CoV-2 infection could be experimentally verified by performing binding assays between SARS-CoV-2 spike and ACE2 receptor proteins under oxidative stress in the absence and presence of PDI

10.1016/j.ejcb.2019.151058 27 WangL.LuoJ

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