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By enhancing pain coping skills and emotional resilience, these interventions contribute to better functional recovery and health-related quality of life (Zhang et al., 2018

Recently, the use of complementary therapy to improve and reduce the symptoms of diabetes mellitus, along with drug therapy and reduced drug dosage, have increased in use [9]

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Indeed, the effects of oral water load on hyaluronidase activity have at present been studied essentially in vitro ( Although the inverse relationship between the renal excretion of hyaluronidase and body hydration has been known since 1958 ( In our study, the changes in hyaluronidase activity were accompanied by broadly comparable variations over time in serum copeptin levels and urinary AQP2/creatinine ratio, which we have previously shown to reliably reflect body water balance and vasopressinergic system activation ( Significantly, prior to oral water load and 4 hours after, that is under physiological conditions in the context of a sodium- and potassium-controlled diet, urinary hyaluronidase activity was positively correlated with SBP levels, which, in turn, were positively associated with the urinary AQP2/creatinine ratio at 0 and 40 min, corresponding to BP rise in response to the oral water load