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However, glutaminase knockout mice (25) or blockade of system A transporters with methylaminoisobutyric acid (MeAIB) (15) fail to block excitatory neurotransmission

Circulation 14 , 161 (1956)

[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Beard RS, Bearden SE

In an ADNP-deficient mouse model (ADNP +/ ), which presents with increased tau hyperphosphorylation, tauopathy-induced memory impairments, and neurodegeneration, 2 weeks of daily 0.5 g IN-NAP to 2 and 9 month old mice partially ameliorated cognitive deficits and reduced tau hyperphosphorylation, showing that even short-term treatment can have significant effects on MCI/AD phenotypes at various stages of degeneration [105]