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It is not intended for human consumption, veterinary use, or any diagnostic, therapeutic, or preventative application

[DOI] [PubMed] [Google Scholar] 88.Sansone A., Di Dato C., de Angelis C., Menafra D., Pozza C., Pivonello R., Isidori A., Gianfrilli D

J Hazard Mater 175:651657

Your circadian rhythm can be interrupted for other reasons besides travel and shift work: Artificial lights (delay melatonin release) Ambient temperature (too hot or too cold) Eating before 8 am or after 6 pm (core temperature increases during digestion) Exercising too close to bedtime (core temperature too hot) Alcohol (reduces melatonin) Caffeine (delays melatonin release) Melatonin release is necessary for sleep and its production is dependent on both the lack of light and the ability of the body to lower its core body temperature