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However, the clinical significance of TMAO generation from L-carnitine supplementation in humans remains under active investigation, and there is currently no official regulatory warning from the MHRA or EMA specifically prohibiting its use on these grounds

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"Fish oil is similar to a stool softener, but it doesn't necessarily soften it it's like a slip and slide," she says, adding that if you take too much, it could lead to diarrhea

(ii) In human studies, this includes differences in race and patient age, as well as sex, diet, and drug use, which can cause changes in the composition of the gut bacterial microbiota and alter the relationship between plasma TMAO levels and atherosclerosis