hek cells glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial Human GSS (Glutathione Synthetase) knockout

Therefore, low cellular energy states will lead to induction of 2-oxoglutarate production via the glutamate dehydrogenase reaction allowing for increased ATP synthesis from the TCA cycle-derived NADH and FADH 2

Nat Med 15:629632 Singh S, Padovani D, Leslie RA, Chiku T, Banerjee R (2009) Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H 2 S biogenesis via alternative trans-sulfuration reactions

PMID: 33005744

Further, NFB modulates the pro-apoptotic actions of c-Jun-amino terminal (stress-activated) kinase, which is also activated by ROS, by inducing the expression of Gadd45, an inhibitor of MAPK (282)