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Nicolson F, Kircher MF, Stone N, Matousek P (2021) Spatially offset Raman spectroscopy for biomedical applications

10.3389/fphar.2023.1156538 129 LiK.WangY.LiuW.ZhangC.XiY.ZhouY.et al (2024)

Must be injected or inhaled. When substances enter directly into the bloodstream via IV, they bypass all four obstacles completely: Needle Bloodstream Available to cells (seconds to minutes) No stomach acid degradation No enzymatic breakdown No intestinal absorption limitations No first-pass hepatic metabolism This is why IV vitamin C can achieve plasma concentrations 100 times higher than oral supplementsthe IV dose avoids all the loss along the digestive pathway

B Enzym 7 (1999) 7783