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SARS-Cov-2 virus infection may initiate a strong inflammatory and dysregulated reaction in the lung with increased levels of IL-6 and a cytokine-storm (129) which has been shown to provoke either an asymptomatic, mild, or severe infections This cytokine dysregulation may be associated with neutrophil extracellular traps (130) and alterations in T cell activity (131)

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Consequently, studies utilize a brain stereotaxic instrument to stereotactically inject 6-OHDA to induce PD, with unilateral injection being the most common method for establishing the 6-OHDA model