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It was suggested that this may have been due to DNA-DNA cross-linking, because thermally denatured DNA will not reanneal in this assay, unless complimentary DNA strands are held together by cross-linkings
PA then diffuses back into the bacilli, where it accumulates and exerts multiple effects against Mtb, including inhibition of fatty acid synthase, disruption of membrane potential, and interference with energy production by interacting with ribosomal protein S1 to inhibit trans-translation (Zimhony et al., 2007
A systematic review and meta-analysis considering the risk for congenital heart defects of antidepressant classes and individual antidepressants
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