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Fukuyama et al

Active Targeting of Nanoparticle Drug Delivery Systems In addition to the EPR effect of drug-loaded nanoparticles and the passive tumor-targeting nanodrug delivery systems designed in response to internal and external stimuli, various ligands can also be conjugated to the surface of nanocarriers based on the overexpression of many receptors on the surface of tumor cells as well as changes in some stem cell markers and subcellular organelles, 128,145,189,203,204 (Figure 5) thereby improving the specific recognition between nanocarriers and cancer cells and playing an active role in tumor targeting

Conversely, GPRC5A displayed heightened expression predominantly within the adjacent normal tissues (Fig

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