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Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0

Enhanced Fat Loss: Some patients have noticed reduced body fat, particularly in stubborn areas resistant to diet and exercise alone

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However, a 2021 case report found that choline injections caused severe skin inflammation and hard nodules in the areas of administration