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Ending with the discharge of the products and renovation of the enzyme in the (E*) form, the subsequent catalytic steps take place once the (E*S) complex is formed [76, 77]

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It plays a significant role in promoting moderate mitochondrial stress, which activates Nrf2, adenosine 5-monophosphate-activated protein kinase (AMPK), and SIRT1 and SIRT3, all of which are involved in anti-inflammatory and antioxidant responses (21, 188)

In 1993 two research groups discovered independently that lipase enzymes induce ROP of -caprolactone (-CL, 7-membered) (Scheme 5a) and -valerolactone (-VL, 6-membered)