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M1 macrophages exhibit bactericidal, pro-inflammatory, and anti-tumor functions, whereas M2 macrophages are primarily involved in tissue repair and anti-inflammatory processes and pro-tumor activities 88
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Peak plasma concentrations were reported to be in the range of 115 M (Novelli and Rosi 2017
This provides transformed hepatocytes with increased tolerance to ROS, increased metabolic flexibility, and resistance to cell death, all of which contribute to tumorigenesis, survival, and drug resistance [3, 12, 13]
