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It also plays an indirect role in energy metabolism

A 2023 review concluded that L-carnitine supplementation may reduce fasting blood sugar and hemoglobin A1c, while also improving insulin sensitivity in people with diabetes, overweight, or obesity

Important differences in methodology may explain these discrepancies

While short-term LC supplementation has demonstrated positive effects, including increased endurance, improved hepatic fat metabolism, and myocardial stability, evidence indicates that the prolonged supplementation may pose risks, particularly for individuals with pre-existing cardiovascular or renal conditions