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Description
Single-cell suspensions of lymphocyte were harvested from mouse liver
While PDE5 is almost undetectable in heathy cardiomyocytes, localized at Z-disks, enzyme expression is significantly upregulated and diffusely distributed in pathologic conditions, such as congestive heart failure, right ventricular hypertrophy, overload hypertrophy, ischemic cardiomyopathy (5558)
Shorter assessment periods don't provide reliable data on whether the higher concentration truly improves outcomes
Nature 468 (7327), 11001104
