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Quantification of carnitine and specific acylcarnitines by high-performance liquid chromatography: application to normal human urine and urine from patients with methylmalonic aciduria, isovaleric acidemia or mediumchain acyl-CoA dehydrogenase deficiency

25 In two randomized placebo-controlled trials, totaling 1257 patients with diabetic neuropathy, Sima and colleagues failed to find any significant electrophysiological change in patients treated with 500 or 1,000 mg ALC, although a significant improvement in the vibration perception threshold was reported

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Eine Interventionsstudie, um die schdliche Wirkung des TMAOs auch beim Menschen nachzuweisen, steht jedoch noch aus