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Ethnic or genetic differences : Some populations naturally glycate hemoglobin differently, which can falsely elevate or lower A1C
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Specifically, calcium-sensing receptors are elevated during infantile cholestasis, and their elevation enhances the activation of p-extracellular signal-regulated kinase (p-ERK) which in turn lessens the expression of apoptotic markers, lowers intracellular calcium, and also inhibits the development of oxidative stress (Qin et al., 2020)
