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(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway

Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan
Mol Endocrinol

Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis
