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When 1 mM of the precursor was supplemented, 15.9 M L-carnitine could be found in the supernatant (1.6% molar yield as judged by the L-carnitine and TML concentrations in the culture medium)

Most patients begin with weekly injections, though some particularly those with significant deficiencies may benefit from two to three injections per week initially

Here we have identified that depletion of -ketoglutarate (KG) sensitizes HR-proficient cells to DNA-damaging agents by metabolic regulation of histone acetylation

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