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Furthermore, rv1127c is truncated, encoding only the PPDK N-terminal ATP-binding domain and the central catalytic histidine kinase domain but not the pyruvate/PEP binding domain (Fig

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There are generalized symptoms related to a vitamin B12 deficiency and neurologic symptoms, both of which include the following signs: Weight loss Nausea or vomiting Diarrhea Fatigue or weakness Mouth sores Decreased appetite Vision problems Numbness in your feet or legs Confusion Irritability Depression You can relate these symptoms to other issues, which is why a vitamin B12 deficiency is sometimes overlooked