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With such tight metal-protein affinities, off-rates to the hydrated state would be so slow as to exceed the lifetimes of proteins before thermodynamic equilibrium is approached: Associative ligand exchange overcomes this limitation

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Alternative product options Non-injectable B12 products that do not require gastric acidity and/or Intrinsic Factor to enhance B12 absorption include Elevated B12 levels B12 levels are rarely monitored once they are within acceptable range, and elevated levels if identified, are not addressed
