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Description
Typically, FRs are attached to the plasma membrane of cells via GPI-anchor and can be released from the membrane by a specific enzyme, the so-called phospholipase C

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However, both the chemical reduction of extracellular cystine by GSH released from astrocytes as well as transfer via extracellular vesicles should not be affected by inhibitors of the astrocytic GT or neuronal aminopeptidase N, which were shown to be involved in the supply of cysteine to neurons (Dringen, Pfeiffer, et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Kim S.H., Vlkolinsky R., Cairns N., Lubec G
