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Insulin resistance is documented in approximately 75% of women with PMOS, regardless of body weight

The loss of these cells can further exacerbate the intestinal barrier dysfunction, creating a vicious cycle that may contribute to the overall pathology observed in SLE patients ( In SLE patients, the gut microenvironment can experience a heightened level of inflammation brought about by the autoimmune nature of the disease

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Furthermore, RIPK1 can form a lethal platform known as complex IIb or ripoptosome with FADD and caspase-8, which is negatively regulated by cIAP1, cIAP2, and X-Linked Inhibitor of Apoptosis Protein (XIAP), and can also activate caspase-8-mediated apoptosis