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MicroRNA 146a is believed to interact with intracellular mediators such as interleukin 1 receptor-associated kinase 1 and mammal-affiliated tumor necrosis factor receptor-associated factor 6, both of which are involved in cytokine-related signal transduction

These include: covering the ulcer with a paste made from baking soda using other topical pastes placing milk of magnesia on the ulcer using a mouth rinse made from salt water and baking soda using a mouth rinse that contains a steroid to reduce pain and swelling applying ice to the ulcer placing a damp tea bag on the ulcer taking supplements if you have deficiencies in certain nutrients, including vitamin B9 (folate), vitamin B12, zinc, and iron using over-the-counter topical products that are made with benzocaine, like Orajel and Anbesol trying natural remedies, such as echinacea, myrrh, and licorice root (may come in various forms, like teas or oils) You can take these steps to help reduce the occurrence of mouth ulcers: Avoid foods that irritate your mouth