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IN-BDNF Therapies for Neuropsychiatric Disorders Major Depressive Disorder BDNFs dysregulation and depletion, particularly in the hippocampus, is well-demonstrated in both postmortem human brain studies of major depressive disorder (MDD) patients and animal models of depression

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Variants in ALDH1A2 reveal an anti-inflammatory role for retinoic acid and a new class of disease-modifying drugs in osteoarthritis

Additionally, pharmacologic activation of PKM2 using TEPP-46 was shown to increase the production of the anti-inflammatory cytokine IL-10 in LPS-activated macrophages via metabolic reprogramming, leading to ATP generation and release derived from glycolysis (77)