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Wang, Microchem

Liver: A rat study found that turmeric extract and curcumin were protective against chronic liver damage by helping reduce harmful oxidative stress

Notably, patients with COPD exhibit reduced expression levels of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2) in their bodies, and this leads to extensive endothelial cell death and microvascular damage upon exposure to cigarette smoke extract, accelerating emphysema progression (81)

It is the main by-product (via biliverdin) from the oxidation and breakdown of the haem moiety arising from red cell destruction (80%) and other proteins, such as myoglobin and catalase (20%), in the reticuloendothelial system tissue of the spleen, bone marrow and so forth