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Based on an elementary inequality called Bonferronis inequality, a conservative critical value for the modified t -statistics is obtained from tables of t -distribution using a significance level of P/m, where m is the number of comparisons between groups to be performed

19 Curcumin is hydrophobic and has poor bioavailability because of its rapid metabolism in the liver and intestinal wall and because it is quickly cleared from the plasma, further limiting its therapeutic utility

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These results indicate that magnesium is necessary for post-insulin receptor activation effects involving GLUT4-mediated uptake of glucose ( Additional research focusing on type 2 diabetic rat models, consisting of magnesium supplementation, showed that magnesium supplementation increases the protein expression of insulin receptors and GLUT4 in skeletal muscle and adipose tissue primarily through improved insulin-signaling efficiency and enhanced activation of downstream pathways such as PI3K/Akt