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A negative correlation between TT genotype and CRC was observed in ethnics of Asians (OR=0.83, 95% CI: 0.76, 0.91), Caucasians (OR=0.93, 95% CI: 0.88, 0.99) and the region of USA (OR=0.77, 95% CI: 0.71, 0.85), Asia (OR=0.93, 95% CI: 0.86, 1.00) and Europe (OR=0.93, 95% CI:0.87, 1.00),but not in Indian (TT: OR=1.67, 95% CI: 1.06, 2.63