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Studies have found that copper can induce neuronal cell ferroptosis, and FeCl2 and CuCl2 can both deplete GSH in mouse hippocampal neurons while enhancing ferroptosis induced by erastin, sulfasalazine (SSZ), and buthionine sulfoximine (BSO)

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Similarly, folate deficiency has been associated with an increased risk of neurodegenerative disorders, where folate supplementation improves cognitive function [23,24,25]

Kroigard T, Svendsen TK, Wirenfeldt M, Schroder HD, Qvortrup C, Pfeiffer P, Gaist D, Sindrup SH.Early changes in tests of peripheral nerve function during oxaliplatin treatment and their correlation with chemotherapy-induced polyneuropathy symptoms and signs