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2023;18 doi: 10.1371/journal.pone.0285523

We therefore tested whether supplementation with excess NAD + and CoA restored lipoylation (Extended Data Fig

Strbe et al., 2021) and analyzed using a semiquantitative neuropathological scoring system, as previously described (Bona et al., 1998

Furthermore, cuprizone intoxication is a useful tool for studying the processes of remyelination, as withdrawal of cuprizone typically results in remyelination in the CNS of the intoxicated animal 21 , albeit at a significantly slower rate following chronic cuprizone intoxication 22
