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An alternative to xCT inhibition is removal of its substrate, cystine
It is evident from MD that the 1-3 arm of #105, #107 and #108 can bind to the GnT-IVa lectin domain in a manner in which 1-2GlcNAc or 1-4GlcNAc occupies the primary GlcNAc binding site
In addition, BSO-induced ferroptosis can be selectively enhanced by chemicals that facilitate PDI activation or PDI-mediated iNOS dimerization or NO accumulation
