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Description
Channel blockers enhanced schistosomicidal activity of compounds To assess the involvement of efflux pumps in the diminished schistosomicidal activity observed in selected compounds ( 7 - 9 ) against S
MRS were aligned by setting the peak of N-acetyl aspartate (NAA) at 2.02 ppm (50)
What they found: Mean weight loss: 2.6 kg vs 2.3 kg placebo , a difference of only 0.3 kg (1 %) Statistically non-significant Clinically unsatisfactory for the obesity indication Safety profile remained favorable Why it matters: The study stopped the development of AOD-9604 as a drug
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