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Well-designed randomized clinical studies are needed to systematically evaluate the evidence for the use of these hepatoprotective agents as treatment options for APAP-induced liver injury, to determine the timing of initiation of the therapy, and to further define the optimal treatment regimen

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Although study heterogeneity and small sample sizes restrict definitive conclusions, positive outcomes have also been observed in patients with diabetic nephropathy, alcoholic liver disease, coronary artery bypass graft patients, and non-alcoholic fatty liver disease (Voroneanu et al., 2017

In this study, the administration of GbE and/or LC significantly reduced both MDA and NO levels and exhibited significant restoration of normal GSH levels and the antioxidant enzymatic activities