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The intraperitoneal application was the last application at 24 h before sacrifice

An intervention trial in 75 adult male smokers found that supplementation with 1,000 mg/day of vitamin C resulted in significantly lower blood lead concentration over a four-week treatment period compared to placebo (219)

The evidence base requires appropriate clinical trials, with additional endpoints including clinical symptoms of patients and additional biochemical parameters beyond plasma B12 levels alone before these alternative routes can be recommended with confidence in clinical guidelines

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