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2015;10: e0121249

Finally, data from various epidemiological, clinical and experimental studies have shown that CR exerts additional beneficial health effects by inhibiting key nutrient-sensing and inflammatory pathways and remains the cornerstone in the prevention and treatment of metabolic disorders [190]

These typically resolve with continued use and may relate to changes in sleep architecture as the body adjusts

The role of Nrf2 in liver fibrosis has been clarified by Lu, who showed that GCL subunits and GS are regulated byNrf2, which binds AREs present in their promoters [2] (Figure 6)