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S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease

AOD-9604 is an intellectually interesting compound whose mechanism is well-characterized in preclinical models, whose safety profile is genuinely clean, and whose clinical program ultimately did not deliver

The severity of clinical findings in methanol intoxication correlated better with formate levels.8 Methanol is gradually released in the small intestine when the methyl group of aspartame encounters the enzyme chymotrypsin,4 but methanol is more readily generated by the body (thus becoming even more dangerous) when it is heated above 30C before being ingested

Inhibition of the Pan-Bcl-2 family by the small molecule GX15-070 induces apoptosis in Mantle cell lymphoma (MCL) cells and enhances the activity of two proteasome inhibitors (NPI-0052 and bortezomib), and doxorubicin chemotherapy