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In Vivo NMR Spectroscopy: Principles and Techniques (Wiley, 2007)

Study Design (design, primary outcome, participants, etc) Design: Double-blind, double-dummy, 22 factorial RCT at 11 UK hospitals from 12/2005 to 11/2008 By double dummy, we mean that there was a sham placebo for each of the study drugs Primary Outcome Change in the percent of the hemithorax taken up by effusion on CXR at day 7 compared to day 1 Key secondary outcomes: Referral for surgery Hospital LOS All cause 3 month and 12 month mortality AEs Participants Inclusion: Clinical evidence of infection (assessed by recruiting MD

Supplementation with spermidine exerts these effects, in part, through the prevention of obesity and the metabolic syndrome in the context of a high-fat diet

SWEETENERS [00149] The term "sweeteners" here denotes substances having a relative sweetening pow er of at least 25, based on the sweetening power of sucrose (which accordingly has a sweet ening power of 1)