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That is the evidence gap, stated plainly: the mechanism is well-motivated and the preclinical signal is consistent, but no human study has confirmed that any of it translates to people, at any dose, by any route

Brown, C

Consequently, the lesions induced in rats share a considerably high degree of similarity with corresponding lesions in human patients

Yeah, well I'm not sure if you're prone to acne, but I am, and I'm very sensitive to many different things
