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Pathak treated an atherosclerotic mouse model with the mechanism-based choline TMA lyase inhibitor IMC, a drug similar to DMB, which can prevent the diet-driven accumulation of cholesterol and change the expression of hepatic genes essential for bile acid feedback regulation ( Ihubacter massiliensis and/or Emergencia timonensis in the human gut can synergistically contribute to diagnosing high-TMAO producers, with 43% sensitivity and 97% specificity (95)

doi: 10.1681/ASN.2013101062 251 VatanenT.KosticA

Heart conversations are nuanced: L-carnitine sits inside the broader DCM and diet-formulation discussion