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These studies, conducted using both in vitro cultured chondrocytes and in vivo OA animal models, have provided strong molecular and phenotypic data

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When adverse reactions have occurred, they have been mild and transient

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Also in hypertension, a deficiency of BH 4 decreases NO synthesis and increases superoxide production, and reduced availability of BH 4 may contribute to the development and maintenance of hypertension

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Effective systemic dose in pigs of 1.1 mg/kg (~75 mg in humans) showed no adverse effects, representing approximately 300-fold below toxic dose

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