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These studies, conducted using both in vitro cultured chondrocytes and in vivo OA animal models, have provided strong molecular and phenotypic data

When adverse reactions have occurred, they have been mild and transient

Also in hypertension, a deficiency of BH 4 decreases NO synthesis and increases superoxide production, and reduced availability of BH 4 may contribute to the development and maintenance of hypertension

Effective systemic dose in pigs of 1.1 mg/kg (~75 mg in humans) showed no adverse effects, representing approximately 300-fold below toxic dose
