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Low back pain refers to several types of pain, such as nociceptive, nociplastic, non-specific, and neuropathic pain

Furthermore, in tumor cells where IGF-1R and INSR are co-expressed, upregulated INSR can compensate for IGF-1R inhibition, thereby limiting sustained inhibition of downstream signaling and contributing to resistance to IGF-1R-targeted therapy [25, 26]

ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells

These non-linearities are addressed below
