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This process is exacerbated by telomere shortening, which occurs naturally with age but can be accelerated by oxidative stress and environmental factors, leading to cellular senescence and decreased melanocyte function

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While these findings clearly support a major role of autoimmunity in SSc genetics, it is less clear whether these SSc susceptibility loci are directly involved in SSc skin fibrosis

[DOI] [PubMed] [Google Scholar] 79.Tacconi M.T., Wurtman R.J
