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Yuena et al

In a hyperglycemic environment, TSPCs undergo aberrant differentiation due to elevated HMGB1 secretion, which regulates this process via the RAGE/catenin signaling pathway [61]

Exogenous Causes: Ultraviolet (UV) radiation exposure Air pollution and environmental toxins Cigarette smoke and tobacco compounds Alcohol consumption Diets high in processed foods and low in antioxidant-rich compounds Sedentary behaviour reducing antioxidant enzyme activity This distinction matters because endogenous and exogenous ROS sources are often studied using different experimental models: in vitro cell studies for endogenous mechanisms, and controlled exposure studies for exogenous triggers

(2012) Kinetics of ergothioneine inhibition of mushroom tyrosinase