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52,53 However, despite the severe liver injury, highly specific LPO parameters such as hydroxy-eicosatetraenoic acids, products of GPx4 activity, and F2-isoprostanes were only increased two- to three-fold above baseline, suggesting minimal LPO

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231 Mechanistically, ketones produced by liver metabolism act as both energy supply molecules and signal molecules involved in binding G protein-coupled receptors, inhibiting HDACs, regulating the abundance of intestinal microbiota, improving intestinal barrier function, and reducing the production of ROS and free radicals